CHCWM – Cancer & Hematology Centers of West Michigan

C4161001 (Pfizer)

Description:  Phase 1/2a Dose Escalation, Finding and Expansion Study Evaluating Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Anti-Tumor Activity of PF-07104091 as a Single Agent and in Combination Therapy.

Mechanism of Action:  CDK2 inhibitor

Target Patient Population:   Small cell Lung Cancer, Platinum Resistant Ovarian, Non-small cell Lung Cancer; in combination with palbociclib and fulvestrant for HR+ HER2- Metastatic Breast Cancer (3rd line plus)

Study Design:  Drug is given orally twice daily.