Description: A Phase 1a/1b Dose Escalation/Expansion Study of TTX-080, an HLA-G Antagonist, as Monotherapy and in Combination with Pembrolizumab or Cetuximab in Patients with Advanced Solid Refractory/Resistant Malignancies.
Target Patient Population: Head and Neck (≤2 prior lines), CRC (≤3 prior lines), NSCLC (≤3 prior lines),Triple Negative Breast (≤2 prior lines)
Study Design: Drug is given IV Day 1, 15 of first 28 day cycle, then day 1 of subsequent cycles